Risks of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors The concomitant usage of tramadol hydrochloride tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) could result in a rise in tramadol plasma stages along with a minimize while in the levels of the Lively metabolite, M1.The effects of concomitant